Bioactive Lipid Mediators in the Initiation and Resolution of Inflammation after Spinal Cord Injury

Neuroinflammation is a prominent feature of the response to CNS trauma. It also an important hallmark various neurodegenerative diseases in which inflammation contributes progression pathology. Inflammation can contribute secondary damage and therefore excellent therapeutic target for range neurological conditions. nervous system complex varies its fine details different involves wide variety secreted factors such as chemokines cytokines, cell adhesion molecules, types that include resident CNS, well immune cells recruited from peripheral circulation. Added this complexity fact some aspects are beneficial, while other induce acute, subacute chronic phases. Understanding these inflammatory profile essential developing effective therapies. Bioactive lipids constitute large group molecules modulate initiation resolution inflammation. Dysregulation bioactive lipid pathways lead excessive acute inflammation, failure resolve by specialized pro-resolution mediators development The focus review discuss effects spinal cord trauma their potential